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Celexa with the brand name of citalopram and it belongs to a class of drugs known as Selective Serotonin Inhibitors. This SSRIs works by raising or restoring serotonin levels and aids to relieve depression. Celexia is used to treat patients that includes patients with major depressive disorder, pregnant women and obsessive-compulsive disorder. Studies states the Celexa can increase the risk of birth defects when administered by a pregnant women; the doses included in these studies were higher than normal therapy doses. This drug is excreted in breast milk and may cause excessive sleepiness or weight loss in a nursing infant so it is not recommended that women is into breastfeeding while taking Celexa.
The New England Journal of Medicine reported that babies exposed to antidepressant drugs such as Celexa in the last trimester were six times more likely to be born with PPHN than babies who are not exposed.
According to the reports, around 12 newborns in 1,000 developed persistent pulmonary hypertension after exposure to SSRIs during pregnancy versus one to two newborns on average.
Newborns with PPHN have abnormal blood flow through their heart and lungs and their bodies are deprived of oxygen. This may cause multiple organ failure in the brain and kidneys. About 20% of babies born with PPHN do not survive and those that do may have long term breathing problems.
Animal studies that make used of large doses of Celexa are reported to show adverse effects on embryo, fetal and postnatal development. There are no similar studies on pregnant woman and therefore, the drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
There is also a warning that newborns exposed to Celexa late in the third trimester developed complications that would lead to prolonged hospitalization, respiratory support and tube feedings.